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Image Search Results
Journal: Cell reports
Article Title: Identification of a Core Amino Acid Motif within the α Subunit of GABA A Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures
doi: 10.1016/j.celrep.2019.06.014
Figure Lengend Snippet: KEY RESOURCES TABLE
Article Snippet:
Techniques: Staining, Recombinant, Saline, Bicinchoninic Acid Protein Assay, Western Blot, Protease Inhibitor, Sequencing, Software, Microscopy
Journal: Neurobiology of disease
Article Title: Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome
doi: 10.1016/j.nbd.2019.104616
Figure Lengend Snippet: α-ARs immunostaining in response to DREADD hM4Di inhibition of the LC. For all α-ARs, the main effects were attributable to treatment since compensatory receptor expressions were seen in (A) Regions examined by α-AR IF. Representative immunofluorescence for α1a-AR comparing all cohorts (parietal region) (B). Normalized fluorescent intensities for (C) α1a-AR (F1,56 = 9.45, p = .003), (D) α2a-AR (F1,56 = 17.2, p = .0001), (E) α2b-AR (F1,44 = 43.91, p < .0001) and (F) α2c-AR (F1,44 = 26.40, p < .0001). A significant effect could also be attributed to karyotype in α1a-AR (F1,56 = 8.40, p = .005), and α2c-AR (F1,44 = 17.73, p = .0001). Scale bar = 100 μm. (G) Expression levels of α2a-, α2b- and α2c-ARs negatively correlated with 24-h NORT DI performance. Error bars represent the mean ± SEM. Dotted lines represented the 95% confidence interval.
Article Snippet: For ARs, sections were incubated overnight at room temperature with anti-β1 (#AAR-023, dil. 1:400), anti-β2 (#AAR-016, dil. 1:200), anti-β3 (#AAR-017, dil. 1:100), anti-α1a (#AAR-015, dil. 1:100), anti-α2a (#AAR-020, dil. 1:200), anti-α2b (#AAR-021, dil. 1:100), or
Techniques: Immunostaining, Inhibition, Immunofluorescence, Expressing